Fast automated meshing for cardiac digital twins

Lead author: Daniel H. Pak

Meshing calcified hearts

DeepCarve (1 second ): Heart tissue, surface + volume meshes

C-MAC (1 minute ): Calcification, add volume meshes with exact conforming surfaces to existing meshes

Verified simulations

Special thanks to Minliang Liu and Caglar Ozturk for the Abaqus simulations!

Abaqus solid results snippet

Abaqus solid mechanics

Abaqus FSI results snippet

Abaqus fluid-structure interaction

NVIDIA Omniverse (real-time)

3D printing & soft robotics

Special thanks to Caglar Ozturk, Luca Rosalia, Debkalpa Goswami, and Mary E. Robakowski for the physical models!

3D printing snippet

Collaborators

This work would not have been possible without our amazing collaborators

Minliang Liu, Caglar Ozturk, Theodore Kim, Luca Rosalia, Debkalpa Goswami, Andres Caballero, Shawn S. Ahn, Yilin Xu, Mary E. Robakowski, John Onofrey, Liang Liang, Raymond McKay, Christopher Nguyen, Ellen T. Roche, Wei Sun, Rudolph Gleason, James S. Duncan (main advisor)

Yale, Georgia Tech, MIT, Texas Tech University, Hartford Hospital, Cleveland Clinic, University of Miami

What's next for us?

1. Assisting end users of our system (code available in Github, instructions below)

2. Accelerating solid simulations

3. Improving & expanding meshing algorithms (bicuspid AV, mitral, echo, more accurate aorta, etc.)

Please do not hesitate to contact us for any related inquiries!

Setup

DeepCarve: full run

C-MAC: full run

BibTeX: DeepCarve

@article{pak2023patient,
  title={Patient-specific Heart Geometry Modeling for Solid Biomechanics using Deep Learning},
  author={Pak, Daniel H and Liu, Minliang and Kim, Theodore and Liang, Liang and Caballero, Andres and Onofrey, John and Ahn, Shawn S and Xu, Yilin and McKay, Raymond and Sun, Wei and others},
  journal={IEEE transactions on medical imaging},
  year={2023},
  publisher={IEEE}
}

@inproceedings{pak2021distortion,
  title={Distortion energy for deep learning-based volumetric finite element mesh generation for aortic valves},
  author={Pak, Daniel H and Liu, Minliang and Kim, Theodore and Liang, Liang and McKay, Raymond and Sun, Wei and Duncan, James S},
  booktitle={Medical Image Computing and Computer Assisted Intervention--MICCAI 2021: 24th International Conference, Strasbourg, France, September 27--October 1, 2021, Proceedings, Part VI 24},
  pages={485--494},
  year={2021},
  organization={Springer}
}

BibTeX: C-MAC

@article{pak2024robust,
  title={Robust automated calcification meshing for biomechanical cardiac digital twins},
  author={Pak, Daniel H and Liu, Minliang and Kim, Theodore and Ozturk, Caglar and McKay, Raymond and Roche, Ellen T and Gleason, Rudolph and Duncan, James S},
  journal={arXiv preprint arXiv:2403.04998},
  year={2024}
}

BibTeX: FSI and 3D printing

coming soon